tuberostemonine
- Product Name
- tuberostemonine
- CAS No.
- 6879-01-2
- Chemical Name
- tuberostemonine
- Synonyms
- Nsc366235;Parathymine;uberostemonine;TuberosteMonin;tuberostemonine;TUBERSTEMONINE(P);Tuberostemonine, 98%, from Stemona tuberosa L.;2β-[(2S,4S)-Tetrahydro-4-methyl-5-oxofuran-2-yl]stenine;NADP+,Parasite,Tuberostemonine,Inhibitor,antimalarial,pfFNR,reductases,falciparum,inhibit,Plasmodium,ferredoxin;(2S,31R,7AR,8R,8aS,11S,11aS,11bR)-8-Ethyl-11-methyl-2-((2S,4S)-4-methyl-5-oxotetrahydrofuran-2-yl)dodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one
- CBNumber
- CB21372283
- Molecular Formula
- C22H33NO4
- Formula Weight
- 375.5
- MOL File
- 6879-01-2.mol
tuberostemonine Property
- Melting point:
- 86～88℃
- Boiling point:
- 554.2±50.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMF:10.0(Max Conc. mg/mL);26.63(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.88(Max Conc. mM)
DMSO:1.0(Max Conc. mg/mL);2.66(Max Conc. mM) - form
- A solid
- pka
- 8.90±0.70(Predicted)
Safety
- HS Code
- 29399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHL83300
- Product name
- Tuberostemonine
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $465
- Updated
- 2024/03/01
- Product number
- 301087
- Product name
- Tuberostemonine
- Packaging
- 20mg
- Price
- $405
- Updated
- 2021/12/16
- Product number
- T897125
- Product name
- Tuberostemonine
- Packaging
- 5mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 468356
- Product name
- Tuberostemonine
- Packaging
- 1mg
- Price
- $312
- Updated
- 2021/12/16
- Product number
- orb259541
- Product name
- Tuberostemonine
- Purity
- 98%
- Packaging
- 20mg
- Price
- $340
- Updated
- 2021/12/16
tuberostemonine Chemical Properties,Usage,Production
Description
This novel alkaloid has been isolated from Sternona sessilifolia and S. tuberosa and was first given the formula C19H29O4N, subsequently altered to that given above. It crystallizes in colourless needles from MeOH with 1 mole of solvent, m.p. 65-88°C (dec.) and has [α]D - 25.4° (Me2CO). It is a non-phenolic, tertiary base and yields a hydrobromide, m.p. 120°C (dec.) and a perchlorate, m.p. 242°C (dec.). The methiodide monohydrate has m.p. 236-8°C (dec.) and the methochloride, dihydrate, m.p. 172°C. A methosulphate has also been prepared, m.p. 253°C (dec.). The base is not hydrolyzed by acids but in the presence of excess PtO2 it gives the dihydro derivative, m.p. 133°C, furnishing a hydrochloride, m.p. 281 ° C. Oxidation with KMnO4 gives a C17 compound, whereas oxidation with silver oxide forms a neutral substance, C22H29O4N, m.p. 178°C which still contains the lactone groups and gives a positive Ehrlich pyrrole reaction.
Uses
Tuberostemonine is elucidated as one of the major components of Radix Stemonae and has been shown to display therapeutic effects against cigarette smoke-induced acute lung inflammation.
Definition
ChEBI: A natural product found in Stemona phyllantha and Stemona tuberosa.
References
Kondo, Suzuki, Satomi.,J. Pharrn. Soc., Japan, 54,96 (1934)
Kondo, Suzuki, Satomi., ibid, 59, 177 (1939)
Kondo, Suzuki, Satomi., ibid, 60, 149 (1940)
Kondo, Suzuki, Satomi., ibid, 61, 111 (1941)
Kaneko., Ann. Rep. ITSUU Lab. (Tokyo), 11,45 (1960)
Gotz, Bogri, Gray., Tetrahedron Lett., 707 (1961)
Edwards, Feniak, Handa., Can. J. Chern., 40,455,2416 (1962)
Crystal structure:
Harada et ai., Chern. Cornrnun., 460 (1967)
tuberostemonine Preparation Products And Raw materials
Raw materials
Preparation Products
tuberostemonine Suppliers
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View Lastest Price from tuberostemonine manufacturers
- Product
- tuberostemonine 6879-01-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-24
- Product
- Tuberstemonine 6879-01-2
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-11-26
- Product
- tuberostemonine 6879-01-2
- Price
- US $8.00/KG
- Min. Order
- 1g
- Purity
- ＞98% HPLC
- Supply Ability
- kg--ton
- Release date
- 2020-02-20